Baldi F, Salera M, Ferrarini F, Milazzo G, Miglioli M, Barbara L
Scand J Gastroenterol. 1980;15(2):171-6. doi: 10.3109/00365528009181450.
Pentagastrin and histamine in doses effective in stimulating gastric acid secretion (5 microgram/kg/h intravenously and 25 microgram/kg intramuscularly, respectively) produce a significant decrease in the gastric mucosal potential difference (PD) in man. In contrast, atropine and cimetidine (2 mg/30 min intravenously and 4.5 mg/kg/h intravenously respectively) cause a significant increase in gastric PD. The subsequent or simultaneous administration of cimetidine reverses the effect of the stimulating agents on gastric PD and pH. Similarly, the subsequent administration of pentagastrin reverses the effect of atropine. The intragastric instillation of 100 c HCl 0.1 N increases significantly the gastric PD valuesp in this case the patterns of PD and pH changes are dissimilar. This study indicates that substances that modify gastric acid secretion also induce changes in gastric PD; this last effect does not seem to depend on variations of the intragastric pH. Therefore, in the clinical evaluation of the gastric PD in man, its multifactorial origin must alway be considered.
五肽胃泌素和组胺以有效刺激胃酸分泌的剂量（分别为静脉注射5微克/千克/小时和肌肉注射25微克/千克）可使人体胃黏膜电位差（PD）显著降低。相比之下，阿托品和西咪替丁（分别为静脉注射2毫克/30分钟和静脉注射4.5毫克/千克/小时）可使胃PD显著升高。随后或同时给予西咪替丁可逆转刺激剂对胃PD和pH的影响。同样，随后给予五肽胃泌素可逆转阿托品的作用。在这种情况下，胃内滴注0.1N的100c HCl可显著提高胃PD值，此时PD和pH变化模式不同。本研究表明，改变胃酸分泌的物质也会引起胃PD的变化；这最后一种效应似乎不取决于胃内pH的变化。因此，在对人体胃PD进行临床评估时，必须始终考虑其多因素起源。
