内源性前列腺素与猫的胃酸分泌：各种分泌抑制剂的作用
Endogenous prostaglandins and stimulated gastric secretion in the cat: the effect of various secretory inhibitors.
作者信息
Baker R, Jaffe B M, Reed J D, Shaw B, Venables C W
出版信息
J Physiol. 1979 Jun;291:1-9. doi: 10.1113/jphysiol.1979.sp012794.
Abstract
- The effects of cimetidine, somatostatin and atropine upon the outputs of acid, pepsin, prostaglandins (PG) E and F in gastric juice secreted in response to i.v. infusions of pentagastrin and histamine (H) have been studied in the conscious gastric fistula cat. 2. At constant rate infusions secretion of PGE occurs and follows a similar pattern to that of gastric acid. However the ratio of H:PGE varies considerably and to an extent inexplicable in terms of assay variation. 3. Inhibition of acid output is matched by inhibition of the output of PGE, but changes in concentration of PGE suggest this is a volume related phenomenon. 4. It is concluded that gastric juice PGE is most unlikely to have a regulatory effect upon acid secretion.
摘要
- 研究了西咪替丁、生长抑素和阿托品对清醒胃瘘猫静脉输注五肽胃泌素和组胺（H）后胃液中酸、胃蛋白酶、前列腺素（PG）E和F分泌量的影响。2. 以恒定速率输注时，PGE分泌出现，且其模式与胃酸分泌相似。然而，H:PGE的比值变化很大，且在某种程度上无法用检测变化来解释。3. 酸分泌的抑制与PGE分泌的抑制相匹配，但PGE浓度的变化表明这是一个与体积相关的现象。4. 得出的结论是，胃液中的PGE极不可能对胃酸分泌产生调节作用。
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