Hohn D C, Meyers A J, Gherini S T, Beckmann A, Markison R E, Churg A M
Surgery. 1980 Jul;88(1):48-58.
The adult respiratory distress syndrome (ARDS) frequently occurs after sepsis and major trauma. Since both sepsis and trauma may cause activation of the complement system, we have infused rabbits with complement-activated plasma (AP) and have studied the effects on leukocyte counts, respiratory rate, PaO2, and lung morphology. Sustained AP infusion caused: (1) early granulocytopenia, (2) progressive hypoxemia and tachypnea, and (3) pulmonary vascular plugging by aggregates of degenerating granulocytes with interstital edema and endothelial injury. These changes were not observed in control animals infused with unactivated plasma or in animals rendered leukopenic with nitrogen mustard. Complement activation in patients with sepsis and trauma may be an etiologic factor in the development of ARDS.
成人呼吸窘迫综合征（ARDS）常发生于脓毒症和严重创伤后。由于脓毒症和创伤均可导致补体系统激活，我们给兔子输注补体激活血浆（AP），并研究其对白细胞计数、呼吸频率、动脉血氧分压（PaO2）及肺形态的影响。持续输注AP导致：（1）早期粒细胞减少；（2）进行性低氧血症和呼吸急促；（3）肺血管被变性粒细胞聚集体阻塞，伴有间质水肿和内皮损伤。在输注未激活血浆的对照动物或用氮芥导致白细胞减少的动物中未观察到这些变化。脓毒症和创伤患者的补体激活可能是ARDS发生发展的一个病因。
