Frank C, Harrer G
Wien Med Wochenschr. 1980 Jan 30;130(2):45-8.
Connections between psychopathological symptoms and chronobiological factors are discussed in the light of a bipolar manic-depressive illness in a female patient suffering during several years from a cycle of 24 hours of depression alternating with one day of hypomania. The forty-eight hour periodic psychosis was evoked by a severe cerebral trauma. All over the world there is only a small number of patients with such regular psychotic cycles. They present a good opportunity to study a conceptual model of desynchronization in phasic psychiatric disorders implying the hypothesis of disturbance of the time structure of functions resulting in a psychotic state.
鉴于一名患有双相躁狂抑郁症的女性患者，其多年来经历了24小时抑郁与1天轻躁狂交替的周期，本文讨论了精神病理症状与生物钟因素之间的联系。48小时周期性精神病是由严重脑外伤诱发的。在世界各地，只有少数患者有如此规律的精神病发作周期。他们为研究阶段性精神障碍中去同步化的概念模型提供了一个很好的机会，这意味着功能时间结构紊乱导致精神病状态的假说。
