Nikitopoulou G, Crammer J L
Br Med J. 1976 May 29;1(6021):1311-4. doi: 10.1136/bmj.1.6021.1311.
The temperatures of six manic-depressive patients were taken every three hours consecutively for many weeks, covering at least one depressive and one manic episode in each patient. While the daily temperature curve was essentially normal in manic phases, with pronounced 24-hour rhythm, during depression the daytime temperatures appeared disorganised, often falling during the morning instead of rising, and with suggestions of a 12-hour rhythm. It may be useful to look on manic-depressive illness as resulting from a desynchronisation of circadian rhythms and to compare the pharmacologies of temperature regulation and mood regulation in psychosis.
连续数周，每三小时测量六名躁郁症患者的体温，每位患者至少经历一次抑郁发作和一次躁狂发作。在躁狂阶段，每日体温曲线基本正常，有明显的24小时节律，而在抑郁阶段，白天体温显得紊乱，常在上午下降而非上升，且有12小时节律的迹象。将躁郁症视为昼夜节律失调所致，并比较精神病中体温调节和情绪调节的药理学，可能会有所帮助。
