Droubay P E, Puppione D L
Am J Clin Nutr. 1980 Jun;33(6):1199-207. doi: 10.1093/ajcn/33.6.1199.
The effects of dietary fat-induced lipemia on arterial oxygen tension and plasma lactate, cholesterol, and triglyceride levels were examined in 11 male subjects (average age 60) with a diagnosis of arteriosclerotic coronary vascular disease and angina pectoris. All subjects were alternately fed three isocaloric formula meals consisting of 100 g of cream fat, 100 g of saffola oil, and an isocaloric nonfat cornstarch control meal. Resting values of arterial blood gases and plasma lactate, triglyceride, and cholesterol were measured before (fasting) and at 3 and 5 hr postprandially. Both types of dietary fat produced significant postprandial decreases in plasma lactate, significant increases in plasma triglyceride and cholesterol levels, and no significant changes in arterial oxygen tension. The control meal had no effect upon any value except to transiently increase the plasma lactate. The role of postprandial lipemia in the atherosclerotic process is discussed and a hypothesis for the plasma cholesterol elevation due to dietary fats is presented.
在11名被诊断患有动脉粥样硬化性冠状动脉疾病和心绞痛的男性受试者（平均年龄60岁）中，研究了饮食脂肪诱导的脂血症对动脉血氧张力以及血浆乳酸、胆固醇和甘油三酯水平的影响。所有受试者交替食用三种等热量配方餐，分别包含100克乳脂、100克红花油，以及一种等热量的无脂玉米淀粉对照餐。在（空腹）餐前以及餐后3小时和5小时测量动脉血气以及血浆乳酸、甘油三酯和胆固醇的静息值。两种类型的饮食脂肪均导致餐后血浆乳酸显著降低、血浆甘油三酯和胆固醇水平显著升高，而动脉血氧张力无显著变化。对照餐除了使血浆乳酸短暂升高外，对其他任何值均无影响。讨论了餐后脂血症在动脉粥样硬化过程中的作用，并提出了饮食脂肪导致血浆胆固醇升高的假说。
