Coustan D R, Berkowitz R L, Hobbins J C
Am J Med. 1980 Jun;68(6):845-52. doi: 10.1016/0002-9343(80)90204-1.
Seventy-three patients with overt diabetes were followed during pregnancy with tight control of carbohydrate metabolism and frequent measurement of glucose levels. During the last 12 weeks of pregnancy, mean plasma glucose levels averaged 108 mg/dl. Mean fasting plasma glucose levels averaged 98 mg/dl. Of the 73 patients, 77 per cent had mean plasma glucose levels of less than 120 mg/dl. Perinatal mortality rate was 4 per cent; this was corrected to 1.4 per cent when congenital anomalies incompatible with life were removed from consideration. Patients were allowed to go as close to term as possible, with 51 per cent being delivered at or beyond 38 weeks. Only two babies (2.8 per cent) were delivered because of deterioration of fetoplacental function test results. The results of this suggest that tight metabolic control may prevent some of the fetal morbidity associated with overt diabetes in pregnancy.
73例显性糖尿病患者在孕期接受了严格的碳水化合物代谢控制及频繁的血糖水平监测。在妊娠的最后12周，平均血浆葡萄糖水平为108mg/dl。平均空腹血浆葡萄糖水平为98mg/dl。73例患者中，77%的平均血浆葡萄糖水平低于120mg/dl。围产期死亡率为4%；当排除与生命不相容的先天性畸形后，该死亡率校正为1.4%。患者尽可能接近足月分娩，51%在38周及以后分娩。仅2例婴儿（2.8%）因胎盘功能试验结果恶化而分娩。该结果表明，严格的代谢控制可能预防一些与孕期显性糖尿病相关的胎儿发病情况。
