色氨酸的直接叔丁基化反应：2,5,7-三叔丁基色氨酸的制备（作者译）

[Direct tert-butylation of tryptophan: preparation of 2,5,7-tri-tert-butyltryptophan (author's transl)].

作者信息

Löw M, Kisfaludy L, Jaeger E, Thamm P, Knof S, Wönsch E

出版信息

Hoppe Seylers Z Physiol Chem. 1978 Dec;359(12):1637-42.

Abstract

The tert-butylation of free tryptophan under simulated conditions of acidolytic cleavage of protecting groups being based on a tert-butyl moiety does finally yield the tri-substituted amino acid as a main product, namely 2,5,7-tri-tert-butyltryptophan. The structural elucidation of this substance and other tert-butylated products, which were isolated mostly in a pure form, was achieved by means of spectroscopic methods, in particular mass spectrometry and nuclear magnetic resonance spectroscopy.

摘要

在基于叔丁基部分的保护基团酸解裂解模拟条件下，游离色氨酸的叔丁基化最终确实得到了三取代氨基酸作为主要产物，即2,5,7-三叔丁基色氨酸。该物质及其他大多以纯形式分离得到的叔丁基化产物的结构解析是通过光谱方法，特别是质谱和核磁共振光谱实现的。