甲氧苄啶及甲氧苄啶-磺胺甲恶唑对耐药性阴道和粪便菌群形成的影响。
Effect of trimethoprim and trimethoprim-sulfamethoxazole on development of drug-resistant vaginal and fecal floras.
作者信息
Pancoast S J, Hyams D M, Neu H C
出版信息
Antimicrob Agents Chemother. 1980 Feb;17(2):263-8. doi: 10.1128/AAC.17.2.263.
Abstract
Trimethoprim-sulfamethoxazole (TMP-SMX) or trimethoprim (TMP) alone was given on a random double-blind basis to 26 young women to treat urinary tract infections. Fecal and introital aerobic bacterial floras were identified at 1, 7, 14, and 42 days to analyze changes in these floras or development of resistance to TMP or TM-SMX. Neither TMP alone nor the TMP-SMX combination administered for 2 weeks selected a resistant fecal or introital flora. In the few individuals who had strains resistant to TMP or TMP-SMX before initiation of therapy, these organisms did not persist once therapy began. Both programs effectively cleared the introitus and rectal areas of Enterobacteriaceae. Concentrations of TMP adequate to inhibit the majority of Escherichia coli strains causing urinary tract infections were found in the vaginal secretions.
摘要
将甲氧苄啶-磺胺甲恶唑（TMP-SMX）或单独的甲氧苄啶（TMP）以随机双盲的方式给予26名年轻女性以治疗尿路感染。在第1、7、14和42天对粪便和阴道需氧菌菌群进行鉴定，以分析这些菌群的变化或对TMP或TMP-SMX耐药性的发展。单独使用TMP或TMP-SMX联合用药2周均未筛选出耐药的粪便或阴道菌群。在治疗开始前少数对TMP或TMP-SMX耐药菌株的个体中，一旦开始治疗，这些微生物就不再持续存在。两种方案均有效地清除了泌尿生殖道和直肠区域的肠杆菌科细菌。在阴道分泌物中发现了足以抑制大多数引起尿路感染的大肠杆菌菌株的TMP浓度。
相似文献
1
Effect of trimethoprim and trimethoprim-sulfamethoxazole on development of drug-resistant vaginal and fecal floras.甲氧苄啶及甲氧苄啶-磺胺甲恶唑对耐药性阴道和粪便菌群形成的影响。
Antimicrob Agents Chemother. 1980 Feb;17(2):263-8. doi: 10.1128/AAC.17.2.263.
2
Resistance among fecal flora of patients taking sulfamethoxazole-trimethoprim or trimethoprim alone.服用复方磺胺甲恶唑或单独服用甲氧苄啶患者粪便菌群的耐药性。
Antimicrob Agents Chemother. 1981 Jan;19(1):33-8. doi: 10.1128/AAC.19.1.33.
3
Emergence of highly trimethoprim-sulfamethoxazole-resistant Shigella in a native American population: an epidemiologic study.美国原住民群体中对甲氧苄啶-磺胺甲恶唑高度耐药的志贺菌的出现：一项流行病学研究。
Am J Epidemiol. 1989 May;129(5):1042-51. doi: 10.1093/oxfordjournals.aje.a115208.
4
Emergence of high-level trimethoprim resistance in fecal Escherichia coli during oral administration of trimethoprim or trimethoprim--sulfamethoxazole.口服甲氧苄啶或甲氧苄啶-磺胺甲恶唑期间粪便中大肠杆菌出现高水平甲氧苄啶耐药性。
N Engl J Med. 1982 Jan 21;306(3):130-5. doi: 10.1056/NEJM198201213060302.
5
Randomized clinical trial of rifampin-trimethoprim and sulfamethoxazole-trimethoprim in the treatment of localized urinary tract infections.利福平-甲氧苄啶与磺胺甲恶唑-甲氧苄啶治疗局限性尿路感染的随机临床试验。
Antimicrob Agents Chemother. 1988 Jun;32(6):802-6. doi: 10.1128/AAC.32.6.802.
6
Trimethoprim-resistant Enterobacteriaceae in urinary tract infection.尿路感染中对甲氧苄啶耐药的肠杆菌科细菌
Can Med Assoc J. 1975 Jun 14;112(13 Spec No):54-8.
7
Trimethoprim-sulfamethoxazole and trimethoprim alone in the prophylaxis of childhood urinary tract infection.甲氧苄啶-磺胺甲恶唑及单独使用甲氧苄啶预防儿童尿路感染
Rev Infect Dis. 1982 Mar-Apr;4(2):461-6. doi: 10.1093/clinids/4.2.461.
8
Prevalence and predictors of trimethoprim-sulfamethoxazole resistance among uropathogenic Escherichia coli isolates in Michigan.密歇根州尿路致病性大肠杆菌分离株中甲氧苄啶-磺胺甲恶唑耐药性的流行情况及预测因素
Clin Infect Dis. 2002 Apr 15;34(8):1061-6. doi: 10.1086/339491. Epub 2002 Mar 11.
9
Incidence of trimethoprim-sulfamethoxazole-resistant enterobacteriaceae among transplant recipients.移植受者中对甲氧苄啶-磺胺甲恶唑耐药的肠杆菌科细菌的发生率。
J Infect Dis. 1984 Nov;150(5):699-706. doi: 10.1093/infdis/150.5.699.
10
A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys.甲氧苄啶-磺胺甲恶唑与单用磺胺甲恶唑治疗局限性肾脏感染的比较。
Can Med Assoc J. 1975 Jun 14;112(13 Spec No):9-12.
引用本文的文献
1
Resistance among fecal flora of patients taking sulfamethoxazole-trimethoprim or trimethoprim alone.服用复方磺胺甲恶唑或单独服用甲氧苄啶患者粪便菌群的耐药性。
Antimicrob Agents Chemother. 1981 Jan;19(1):33-8. doi: 10.1128/AAC.19.1.33.
2
Trimethoprim: a review of its antibacterial activity, pharmacokinetics and therapeutic use in urinary tract infections.甲氧苄啶：其抗菌活性、药代动力学及在尿路感染中的治疗应用综述
Drugs. 1982 Jun;23(6):405-30. doi: 10.2165/00003495-198223060-00001.
3
Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy.复方新诺明（甲氧苄啶-磺胺甲恶唑）：抗菌活性及临床疗效的最新综述
Drugs. 1982 Dec;24(6):459-518. doi: 10.2165/00003495-198224060-00002.
4
Emergence of trimethoprim resistance in fecal flora.粪便菌群中出现甲氧苄啶耐药性。
Antimicrob Agents Chemother. 1985 Aug;28(2):354-6. doi: 10.1128/AAC.28.2.354.
5
Surveillance cultures and benefit of laminar airflow units in patients undergoing bone marrow transplantation.
Infection. 1987;15(5):337-43. doi: 10.1007/BF01647734.
6
Risk factors for fecal colonization with trimethoprim-resistant and multiresistant Escherichia coli among children in day-care centers in Houston, Texas.德克萨斯州休斯顿日托中心儿童中耐甲氧苄啶和多重耐药大肠杆菌粪便定植的危险因素。
Antimicrob Agents Chemother. 1990 Jul;34(7):1429-34. doi: 10.1128/AAC.34.7.1429.
本文引用的文献
1
Trimethoprim, a sulphonamide potentiator.甲氧苄啶，一种磺胺增效剂。
Br J Pharmacol Chemother. 1968 May;33(1):72-90. doi: 10.1111/j.1476-5381.1968.tb00475.x.
2
[Antibacterial activity of the combination trimethoprim-sulfamethoxazole compared with antibiotics].
Schweiz Med Wochenschr. 1969 Oct 18;99(42):1505-10.
3
Long-term treatment of persistent or recurrent urinary tract infection with trimethoprim-sulfamethoxazole.用甲氧苄啶-磺胺甲恶唑长期治疗持续性或复发性尿路感染。
J Infect Dis. 1973 Nov;128:Suppl:652-6 p. doi: 10.1093/infdis/128.supplement_3.s652.
4
Trimethoprim R factors in enterobacteria from clinical specimens.临床标本中肠杆菌科细菌的甲氧苄啶R因子
J Med Microbiol. 1974 May;7(2):169-77. doi: 10.1099/00222615-7-2-169.
5
Synergistic activity of trimethoprim-sulfamethoxazole on gram-negative bacilli: observations in vitro and in vivo.甲氧苄啶-磺胺甲恶唑对革兰氏阴性杆菌的协同活性：体内外观察
J Infect Dis. 1973 Nov;128:Suppl:470-7 p. doi: 10.1093/infdis/128.supplement_3.s470.
6
Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection.比较氨苄西林、头孢氨苄、复方新诺明和甲氧苄啶治疗尿路感染的双盲试验。
Br Med J. 1972 Jun 17;2(5815):673-6. doi: 10.1136/bmj.2.5815.673.
7
Trimethoprim resistance determined by R factors.由R因子决定的甲氧苄啶耐药性。
Br Med J. 1972 Mar 18;1(5802):726-8. doi: 10.1136/bmj.1.5802.726.
8
The effect of a combined preparation of trimethoprim and sulphamethoxazole following short-term and long-term administration on the flora of the human gut.短期和长期服用甲氧苄啶与磺胺甲恶唑复方制剂对人体肠道菌群的影响。
Chemotherapy. 1973;18(5):285-96. doi: 10.1159/000221273.
9
Effect of trimethoprim on the occurrence of drug-resistant coliform bacteria in the faecal flora.甲氧苄啶对粪便菌群中耐药性大肠菌发生情况的影响。
Chemotherapy. 1976;22(2):97-103. doi: 10.1159/000221918.
10
Antimicrobial resistance and R-factor transfer among isolates of Salmonella in the northeastern United States: a comparison of human and animal isolates.
J Infect Dis. 1975 Dec;132(6):617-22. doi: 10.1093/infdis/132.6.617.
Zotero 插件