甲型流感活疫苗的基因组合
Gene constellation of live influenza A vaccines.
作者信息
Florent G
出版信息
Arch Virol. 1980;64(2):171-3. doi: 10.1007/BF01318021.
PMID:7387405
Abstract
The genotypic composition of several H3N2 vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 "polymerase proteins" are responsible for their consistent attenuation.
摘要
已确定了几种由PR/8/34和不同野生分离株制成的H3N2疫苗株的基因型组成。结果表明，编码3种“聚合酶蛋白”的3个最大RNA片段水平上的特定基因组合导致了它们持续的减毒。
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