von Blomberg B M, Glerum J, Croles J J, Stam J, Drexhage H A
Br J Cancer. 1980 Apr;41(4):609-17. doi: 10.1038/bjc.1980.104.
The effects are reported of a combination therapy of i.v. C. parvum and cyclophosphamide on the survival time and immune responses of patients with inoperable squamous-cell carcinoma of the bronchus. The immune status of the patients was evaluated by determining the antibody response to C. parvum, the E and EAC rosettes, the PHA response of blood lymphocytes, the skin-test reactivity to Candida and PPD, the response to DNCB and the chemotaxis and NBT-dye reduction capacity of neutrophil leucocytes. The survival time of patients treated with the combination therapy was found to be significantly shorter than that of untreated patients and of those receiving cyclophosphamide only. Severe side effects were observed after C. parvum infusions, with no decrease on repeated administration. The effect of C. parvum on the different immune parameters of cyclophosphamide-treated patients was negligible, though there was a normal antibody response to C. parvum.
报告了静脉注射微小隐孢子虫与环磷酰胺联合治疗对无法手术的支气管鳞状细胞癌患者生存时间和免疫反应的影响。通过测定对微小隐孢子虫的抗体反应、E和EAC玫瑰花结、血液淋巴细胞的PHA反应、对念珠菌和PPD的皮肤试验反应性、对DNCB的反应以及中性粒细胞的趋化性和NBT染料还原能力来评估患者的免疫状态。发现接受联合治疗的患者的生存时间明显短于未治疗的患者和仅接受环磷酰胺治疗的患者。微小隐孢子虫输注后观察到严重的副作用,重复给药后无减轻。微小隐孢子虫对环磷酰胺治疗患者的不同免疫参数的影响可忽略不计,尽管对微小隐孢子虫有正常的抗体反应。