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1
Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus.静脉注射短小棒状杆菌与环磷酰胺同时给予支气管鳞状细胞癌患者的有害影响。
Br J Cancer. 1980 Apr;41(4):609-17. doi: 10.1038/bjc.1980.104.
2
Corynebacterium parvum: antibodies measured with the enzyme-linked immunosorbent assay (ELISA) in normal human sera and sera from cancer patients undergoing treatment.微小棒状杆菌：在正常人血清以及接受治疗的癌症患者血清中用酶联免疫吸附测定法（ELISA）检测的抗体。
Ann Immunol (Paris). 1982 Nov-Dec;133D(3):305-11.
3
Intravenous Corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer.静脉注射短小棒状杆菌：耐药晚期卵巢癌化疗的辅助治疗手段
Cancer. 1977 Feb;39(2):514-26. doi: 10.1002/1097-0142(197702)39:2<514::aid-cncr2820390220>3.0.co;2-#.
4
Inhibitory effect of prolonged Corynebacterium parvum and cyclophosphamide administration on the growth of established tumors.长期给予短小棒状杆菌和环磷酰胺对已形成肿瘤生长的抑制作用。
Cancer. 1975 Jan;35(1):134-43. doi: 10.1002/1097-0142(197501)35:1<134::aid-cncr2820350119>3.0.co;2-g.
5
An evaluation of Corynebacterium parvum during remission maintenance therapy in pediatric patients with acute lymphoblastic leukemia.小棒状杆菌在儿童急性淋巴细胞白血病缓解期维持治疗中的评估。
Med Pediatr Oncol. 1979;6(2):101-14. doi: 10.1002/mpo.2950060203.
6
Moderate to high dose cyclophosphamide and intercalated Corynebacterium parvum in patients with metastatic lung cancer.中高剂量环磷酰胺与小棒状杆菌在转移性肺癌患者中的联合应用
Br J Dis Chest. 1984 Jan;78(1):89-97.
7
Combination chemoimmunotherapy for extensive non-oat cell lung cancer.广泛期非小细胞肺癌的联合化疗免疫治疗
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8
Further observations on the inhibition of tumor growth by Corynebacterium parvum with cyclophosphamide. III. Effect of C. parvum on cyclophosphamide metabolism.短小棒状杆菌与环磷酰胺联合抑制肿瘤生长的进一步观察。III. 短小棒状杆菌对环磷酰胺代谢的影响。
J Natl Cancer Inst. 1976 Jul;57(1):225-6. doi: 10.1093/jnci/57.1.225.
9
[Recent personal results in advanced bronchial cancer. Palliative immuno-chemotherapy. 63 cases].[晚期支气管癌的近期个人治疗结果。姑息性免疫化疗。63例]
Ann Med Interne (Paris). 1976 Jan;127(1):39-42.
10
Toxicity manifestations following intravenous Corynebacterium parvum administration to patients with ovarian and cervical carcinoma.对卵巢癌和宫颈癌患者静脉注射短小棒状杆菌后的毒性表现。
Am J Obstet Gynecol. 1978 Nov 1;132(5):555-60. doi: 10.1016/0002-9378(78)90752-4.

引用本文的文献

1
Lower relapse rates after neighbourhood injection of Corynebacterium parvum in operable cervix carcinoma.可手术宫颈癌患者局部注射短小棒状杆菌后复发率降低。
Br J Cancer. 1981 Dec;44(6):856-62. doi: 10.1038/bjc.1981.284.

本文引用的文献

1
Active immunotherapy with Corynebacterium parvum and chemotherapy in murine fibrosarcomas.短小棒状杆菌主动免疫疗法与化疗对小鼠纤维肉瘤的作用
Br Med J. 1970 Feb 28;1(5695):541-4. doi: 10.1136/bmj.1.5695.541.
2
Patient survival after chemotherapy and its relationship to in vitro lymphocyte blastogenesis.化疗后的患者生存率及其与体外淋巴细胞增殖的关系。
Cancer. 1971 Oct;28(4):851-5. doi: 10.1002/1097-0142(1971)28:4<851::aid-cncr2820280408>3.0.co;2-e.
3
Clinical immunologic responsiveness in malignant disease. II. In vitro lymphocyte response to phytohemagglutinin and the effect of cytotoxic drugs.恶性疾病中的临床免疫反应性。II. 淋巴细胞对植物血凝素的体外反应及细胞毒性药物的作用。
Oncology. 1972;26(4):357-68. doi: 10.1159/000224687.
4
Oxygen consumption of phagocytizing cells in human leukocyte and granulocyte preparations: a comparative study.人白细胞和粒细胞制剂中吞噬细胞的耗氧量：一项比较研究。
J Lab Clin Med. 1974 Apr;83(4):570-7.
5
Leukocyte locomotion and chemotaxis. New methods for evaluation, and demonstration of a cell-derived chemotactic factor.白细胞移动与趋化性。评估及证明一种细胞源性趋化因子的新方法。
J Exp Med. 1973 Feb 1;137(2):387-410. doi: 10.1084/jem.137.2.387.
6
Lung cancer: perspectives and prospects.肺癌：观点与展望
Ann Intern Med. 1970 Dec;73(6):1003-24. doi: 10.7326/0003-4819-73-6-1003.
7
Further observations on the inhibition of tumor growth by Corynebacterium parvum with cyclophosphamide. I. Variation in administration of both agents.关于短小棒状杆菌与环磷酰胺联合抑制肿瘤生长的进一步观察。I. 两种药物给药方式的变化
J Natl Cancer Inst. 1975 Nov;55(5):1147-53. doi: 10.1093/jnci/55.5.1147.
8
Inhibitory effect of prolonged Corynebacterium parvum and cyclophosphamide administration on the growth of established tumors.长期给予短小棒状杆菌和环磷酰胺对已形成肿瘤生长的抑制作用。
Cancer. 1975 Jan;35(1):134-43. doi: 10.1002/1097-0142(197501)35:1<134::aid-cncr2820350119>3.0.co;2-g.
9
E and EAC rosette-forming cells in healthy donors and cancer patients.健康供体和癌症患者中的E和EAC玫瑰花结形成细胞。
Int Arch Allergy Appl Immunol. 1976;52(1-4):412-6. doi: 10.1159/000231708.
10
The effect of Corynebacterium parvum on the humoral and cellular immune systems in patients with breast cancer.短小棒状杆菌对乳腺癌患者体液免疫和细胞免疫系统的影响。
Clin Exp Immunol. 1976 Jun;24(3):441-7.

静脉注射短小棒状杆菌与环磷酰胺同时给予支气管鳞状细胞癌患者的有害影响。

Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus.

作者信息

von Blomberg B M, Glerum J, Croles J J, Stam J, Drexhage H A

出版信息

Br J Cancer. 1980 Apr;41(4):609-17. doi: 10.1038/bjc.1980.104.

DOI:10.1038/bjc.1980.104
PMID:7387858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2010289/
Abstract

The effects are reported of a combination therapy of i.v. C. parvum and cyclophosphamide on the survival time and immune responses of patients with inoperable squamous-cell carcinoma of the bronchus. The immune status of the patients was evaluated by determining the antibody response to C. parvum, the E and EAC rosettes, the PHA response of blood lymphocytes, the skin-test reactivity to Candida and PPD, the response to DNCB and the chemotaxis and NBT-dye reduction capacity of neutrophil leucocytes. The survival time of patients treated with the combination therapy was found to be significantly shorter than that of untreated patients and of those receiving cyclophosphamide only. Severe side effects were observed after C. parvum infusions, with no decrease on repeated administration. The effect of C. parvum on the different immune parameters of cyclophosphamide-treated patients was negligible, though there was a normal antibody response to C. parvum.

摘要

报告了静脉注射微小隐孢子虫与环磷酰胺联合治疗对无法手术的支气管鳞状细胞癌患者生存时间和免疫反应的影响。通过测定对微小隐孢子虫的抗体反应、E和EAC玫瑰花结、血液淋巴细胞的PHA反应、对念珠菌和PPD的皮肤试验反应性、对DNCB的反应以及中性粒细胞的趋化性和NBT染料还原能力来评估患者的免疫状态。发现接受联合治疗的患者的生存时间明显短于未治疗的患者和仅接受环磷酰胺治疗的患者。微小隐孢子虫输注后观察到严重的副作用，重复给药后无减轻。微小隐孢子虫对环磷酰胺治疗患者的不同免疫参数的影响可忽略不计，尽管对微小隐孢子虫有正常的抗体反应。