银屑病斑块中的有丝分裂指数及其对补骨脂素加紫外线A光疗法（PUVA疗法）的反应。

The mitotic index in psoriatic plaques and their response to PUVA therapy.

作者信息

Goldberg L H, Cox A J, Abel E A

出版信息

Br J Dermatol. 1980 Apr;102(4):401-5. doi: 10.1111/j.1365-2133.1980.tb06552.x.

DOI:10.1111/j.1365-2133.1980.tb06552.x

Abstract

The mitotic index of pretreatment plaques of chronic psoriasis was determined before treatment with PUVA. There was a wide variation in mitotic indices in different patients. Treatment was given with UV-A 2 h after oral ingestion of 8-methoxypsoralen (8-MOP) two or three times per week, with increasing doses of UV-A. Patients were considered cleared if there was 95% clearing of all psoriatic plaques. There was no correlation between the mitotic index and the response to treatment, as measured by either the number of joules administered or the number of treatments until the lesions cleared. This suggests that the action of PUVA in psoriasis is not dependent on the amount of increase in epidermal proliferation.

摘要

在使用补骨脂素联合紫外线A（PUVA）治疗前，测定了慢性银屑病预处理斑块的有丝分裂指数。不同患者的有丝分裂指数差异很大。每周口服8-甲氧基补骨脂素（8-MOP）两到三次，2小时后给予紫外线A治疗，紫外线A剂量逐渐增加。如果所有银屑病斑块清除率达到95%，则认为患者已治愈。有丝分裂指数与治疗反应之间没有相关性，治疗反应通过给予的焦耳数或病变清除前的治疗次数来衡量。这表明PUVA在银屑病中的作用不依赖于表皮增殖的增加量。