Bird A C, el-Sheikh H, Anderson J, Fuglsang H
Br J Ophthalmol. 1980 Mar;64(3):191-200. doi: 10.1136/bjo.64.3.191.
Eighteen patients, moderately to heavily infected with onchocerciasis, were treated with a standard course of diethylcarbamazine citrate (DEC-C). In addition to the well recognised systemic reactions to treatment, the following ocular changes occurred during therapy: (1) Transient pigment epithelial lesions were detected in 7 patients by fluorescein angiography. (2) Optic disc leakage, as shown by fluorescein angiography, developed in 9 patients, and increase of pre-existing leakage was demonstrated in 3 further patients. (3) Visual field loss was documented in 5 patients. These observations have grave implications for DEC-C therapy in onchocerciasis. They emphasise the need for great caution in its use in the treatment of onchocerciasis in heavily infected patients and for close supervision of ocular function during therapy.
18例中度至重度盘尾丝虫病感染患者接受了标准疗程的枸橼酸乙胺嗪（DEC-C）治疗。除了对治疗普遍认可的全身反应外，治疗期间还出现了以下眼部变化：（1）7例患者经荧光素血管造影检测到短暂性色素上皮病变。（2）9例患者经荧光素血管造影显示视盘渗漏，另有3例患者原有渗漏增加。（3）5例患者记录到视野缺损。这些观察结果对盘尾丝虫病的DEC-C治疗具有严重意义。它们强调在重度感染患者的盘尾丝虫病治疗中使用该药时需极其谨慎，并在治疗期间密切监测眼部功能。
