Agasarov L G
Biull Eksp Biol Med. 1980 Mar;89(3):284-6.
Incubation of alveolar macrophages of rabbits and peritoneal macrophages of the abdominal cavity washing of albino mice does not lead to endogenous pyrogen release. Peritoneal macrophages obtained after peritoneal administration to mice of thioglycollate, glycogen or heterologous blood cells do not discharge pyrogen either during incubation without additional stimulation. Macrophages isolated after intraperitoneal administration of heterologous blood cells do not exhibit pyrogenic activity possibly because of a long period of time elapsed after phagocytosis of foreign agents. The triggering of pyrogen formation by macrophages can be effected by means of in vitro phagocytosis of corpuscular particles: staphylococci or heterologous blood cells.
兔肺泡巨噬细胞与白化小鼠腹腔灌洗获得的腹腔巨噬细胞孵育不会导致内源性致热原释放。给小鼠腹腔注射巯基乙酸盐、糖原或异源血细胞后获得的腹腔巨噬细胞，在无额外刺激的孵育过程中也不释放致热原。腹腔注射异源血细胞后分离的巨噬细胞不表现出发热活性，可能是因为吞噬外源物质后经过了很长时间。巨噬细胞致热原形成的触发可通过体外吞噬颗粒物质（葡萄球菌或异源血细胞）来实现。
