Sorokin A V, Agasarov L G, Efremov O M
Biull Eksp Biol Med. 1980 Mar;89(3):278-81.
Activation of mononuclear phagocytes by staphylococci in vitro results in the production of endogenous pyrogen. Macrophage pyrogen does not posses species pyrogenic specificity. Intracisternal injection increases pyrogen susceptibility more than 100-fold as compared to intravenous injection. Still more abrupt increase in pyrogen susceptibility was observed in the animals in the presence of elevated body cAMP concentration induced by theophylline preinjection.
体外葡萄球菌激活单核吞噬细胞可导致内源性热原的产生。巨噬细胞热原不具有种属热原特异性。与静脉注射相比，脑池内注射可使热原敏感性增加100倍以上。在预先注射茶碱诱导机体cAMP浓度升高的动物中，观察到热原敏感性的增加更为突然。
