单核吞噬细胞与成纤维细胞或海拉细胞产生热原的差异。
Differences in pyrogen production by mononuclear phagocytes and by fibroblasts or HeLa cells.
作者信息
Bodel P, Miller H
机构信息
Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06510.
出版信息
J Exp Med. 1977 Mar 1;145(3):607-17. doi: 10.1084/jem.145.3.607.
Abstract
Phagocytosis of bacteria stimulates "professional" phagocytes to produce and release endogenous pyrogen (EP), the protein that mediates fever. To determine whether "nonprofessional" phagocytes also have this capacity, mouse and human fibroblasts and HeLa cells were cultured after ingestion of latex or chicken erythrocytes (CE), and EP release into culture supernate measured by mouse assay. No detectable pyrogen was released by these cell types after phagocytosis, whereas both latex and CE stimulated EP production by cultured mouse macrophages. These studies support the hypothesis that only professional phagocytes of bone marrow origin synthesize EP and induce fever.
摘要
细菌的吞噬作用刺激“专职”吞噬细胞产生并释放内源性致热原（EP），这是一种介导发热的蛋白质。为了确定“非专职”吞噬细胞是否也有这种能力，在小鼠和人类成纤维细胞以及HeLa细胞摄取乳胶或鸡红细胞（CE）后进行培养，并用小鼠试验测定培养上清液中EP的释放量。这些细胞类型在吞噬作用后未释放可检测到的致热原，而乳胶和CE均刺激培养的小鼠巨噬细胞产生EP。这些研究支持了以下假说，即只有源自骨髓的专职吞噬细胞才能合成EP并引起发热。
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本文引用的文献
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