Tanner W A, Delaney P V, Hennessy T P
Br J Surg. 1980 May;67(5):311-2. doi: 10.1002/bjs.1800670503.
In a prospective study of 108 intravenous infusions a significant decrease was noted in the incidence of both cannula-related sepsis and cannula-related phlebitis in those patients on low dose (1000 units/1000 ml infusate) heparin given intravenously. A significant decrease in the incidence of cannula-related phlebitis was also noted in patients receiving subcutaneous low dose heparin (5000 units 8-hourly). This significant decrease may be due to inhibition of fibrin clot formation around the tip of the indwelling intravenous cannula.
在一项针对108次静脉输注的前瞻性研究中，发现接受静脉注射低剂量（1000单位/1000毫升输注液）肝素的患者，与套管相关的败血症和与套管相关的静脉炎的发生率均显著降低。接受皮下低剂量肝素（每8小时5000单位）的患者，与套管相关的静脉炎发生率也显著降低。这种显著降低可能是由于抑制了留置静脉套管尖端周围纤维蛋白凝块的形成。
