Morris T, Appbly R
Br J Surg. 1980 Jun;67(6):391-2. doi: 10.1002/bjs.1800670603.
Lignocaine has previously been shown to retard wound healing; the retardation is directly related to the concentration of the drug used and is enhanced by the addition of adrenaline. The study described in this paper aimed to determine whether procaine has a similar effect and, if so, whether the effect of sterile water alone and of procaine in various concentrations on the tensile strength of skin wounds in rats. 5 and 7 days after operation. At 5 days sterile water had produced a significant retardation of wound healing. All concentrations of procaine produced significant retardation of healing at 5 days and adrenaline enhanced this effect. By 7 days the effect was greatly diminished and only those rats injected with 2 per cent procaine with adrenaline had significantly weaker wounds. The study suggests that 2 per cent procaine with adrenaline is better avoided and even when lower concentrations are used sutures should be retained for 7 days.
利多卡因先前已被证明会延缓伤口愈合；这种延缓与所用药物的浓度直接相关，并且加入肾上腺素会增强这种作用。本文所述的研究旨在确定普鲁卡因是否有类似作用，如果有，单独的无菌水以及不同浓度的普鲁卡因对大鼠皮肤伤口抗张强度的影响。术后5天和7天。在术后5天时，无菌水已显著延缓了伤口愈合。所有浓度的普鲁卡因在术后5天时均显著延缓了愈合，并且肾上腺素增强了这种作用。到术后7天时，这种作用大大减弱，只有那些注射了2%含肾上腺素普鲁卡因的大鼠伤口明显较弱。该研究表明应尽量避免使用2%含肾上腺素的普鲁卡因，即使使用较低浓度时，缝线也应保留7天。
