Morris T, Tracey J
Br J Surg. 1977 Dec;64(12):902-3. doi: 10.1002/bjs.1800641219.
In the light of clinical observations that local anaesthetic impairs wound healing, the effect of lignocaine at various concentrations, with and without adrenaline, on the tensile strength of skin wounds in rats 3, 5 and 7 days after operation was studied. Lignocaine had an adverse effect on wound healing at 5 and 7 days, perhaps due partly to the destructive effect of the intra- and subcutaneous injection, but certainly due also to the lignocaine itself. Adrenaline potentiated this effect. It was concluded that it is better to use dilute solutions of lignocaine, preferably without adrenaline, for local anaesthesia.
鉴于临床观察发现局部麻醉剂会损害伤口愈合，研究了利多卡因在不同浓度下（含或不含肾上腺素）对大鼠皮肤伤口术后3天、5天和7天抗张强度的影响。利多卡因在术后5天和7天对伤口愈合有不良影响，部分原因可能是肌内和皮下注射的破坏作用，但肯定也与利多卡因本身有关。肾上腺素会增强这种作用。得出的结论是，局部麻醉最好使用稀释的利多卡因溶液，最好不含肾上腺素。
