缺铁性贫血患儿的体液免疫反应
Humoral immune response in children with iron-deficiency anaemia.
作者信息
Bagchi K, Mohanram M, Reddy V
出版信息
Br Med J. 1980 May 24;280(6226):1249-51. doi: 10.1136/bmj.280.6226.1249.
The humoral immune response (as shown by plasma immunoglobulin concentrations and antibody response to diphtheria and tetanus toxoids) was evaluated in 14 children with iron-deficiency anaemia and in 24 normal controls. Mean concentrations of haemoglobin and serum iron and mean transferrin saturation were significantly lower in children with iron-deficiency anaemia than in controls. Serum immunoglobulin concentrations were within the normal range in both groups. Two weeks after immunisation with diphtheria and tetanus toxoids the concentrations of IgG increased significantly in both groups. Antibody titres in iron-deficient children were similar to those of controls before and after immunisation. The mean T-lymphocyte count was significantly lower in iron-deficient children than that in controls, but the mean B-lymphocyte counts were similar in the two groups. These observations suggest that humoral immunity in children is not affected by iron deficiency and that conventional immunisation programmes would be effective in children with iron-deficiency anaemia.
对14名缺铁性贫血儿童和24名正常对照儿童的体液免疫反应（通过血浆免疫球蛋白浓度以及对白喉和破伤风类毒素的抗体反应来显示）进行了评估。缺铁性贫血儿童的血红蛋白和血清铁平均浓度以及转铁蛋白平均饱和度显著低于对照组。两组的血清免疫球蛋白浓度均在正常范围内。用白喉和破伤风类毒素免疫两周后，两组的IgG浓度均显著升高。缺铁儿童免疫前后的抗体滴度与对照组相似。缺铁儿童的平均T淋巴细胞计数显著低于对照组，但两组的平均B淋巴细胞计数相似。这些观察结果表明，儿童的体液免疫不受缺铁影响，传统免疫程序对缺铁性贫血儿童有效。
Zotero 插件