West S G, Pittman D L, Coggin J T
Cancer. 1980 Jul 15;46(2):330-5. doi: 10.1002/1097-0142(19800715)46:2<330::aid-cncr2820460220>3.0.co;2-m.
The first case of an intracranial plasma cell granuloma is presented. An associated polyclonal gammopathy was another remarkable feature. Routine and special stains of histologic sections as well as electron microscopy characterized such lesions. Immunofluorescent studies revealed a heterogeneous population of plasma cells. When the granuloma was removed, the polyclonal gammopathy resolved, and neither have recurred with eight months of follow-up. It is suggested that prior reports of meningiomas with conspicuous plasma cell-lymphocytic components may in reality be plasma cell granulomas and could be differentiated by electron microscopy.
本文报告了首例颅内浆细胞肉芽肿病例。相关的多克隆丙种球蛋白病是另一个显著特征。组织学切片的常规和特殊染色以及电子显微镜检查对这类病变进行了特征性描述。免疫荧光研究显示浆细胞群体具有异质性。当肉芽肿被切除后，多克隆丙种球蛋白病得以缓解，且在八个月的随访中均未复发。有人提出，先前报道的具有明显浆细胞 - 淋巴细胞成分的脑膜瘤实际上可能是浆细胞肉芽肿，可通过电子显微镜进行鉴别。
