• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

动物细胞中碳水化合物代谢的调节:中国仓鼠卵巢细胞糖酵解变体的分离

The regulation of carbohydrate metabolism in animal cells: isolation of a glycolytic variant of Chinese hamster ovary cells.

作者信息

Morgan M J, Faik P

出版信息

Cell Biol Int Rep. 1980 Feb;4(2):121-7. doi: 10.1016/0309-1651(80)90066-1.

DOI:10.1016/0309-1651(80)90066-1
PMID:7388964
Abstract

A variant of Chinese hamster ovary cells is described which is deficient in two glycolytic enzymes: glucosephosphate isomerase and phosphoglycerate kinase. The variant grows readily on glucose, but in contrast to the parental cell it does not excrete lactic acid. The impaired ability of the variant to perform aerobic glycolysis both in vivo and in vitro is correlated with the deficiency in both glycolytic enzymes.

摘要

描述了一种中国仓鼠卵巢细胞变体,其缺乏两种糖酵解酶:葡萄糖磷酸异构酶和磷酸甘油酸激酶。该变体在葡萄糖上易于生长,但与亲代细胞不同的是,它不分泌乳酸。该变体在体内和体外进行有氧糖酵解的能力受损与两种糖酵解酶的缺乏相关。

相似文献

1
The regulation of carbohydrate metabolism in animal cells: isolation of a glycolytic variant of Chinese hamster ovary cells.动物细胞中碳水化合物代谢的调节:中国仓鼠卵巢细胞糖酵解变体的分离
Cell Biol Int Rep. 1980 Feb;4(2):121-7. doi: 10.1016/0309-1651(80)90066-1.
2
Regulation of carbohydrate metabolism in cultured mammalian cells: energy provision in a glycolytic mutant.培养的哺乳动物细胞中碳水化合物代谢的调节:糖酵解突变体中的能量供应
Biosci Rep. 1981 Oct;1(10):811-7. doi: 10.1007/BF01114804.
3
The regulation of carbohydrate metabolism in animal cells: isolation of a glycolytic variant.
Biochem Soc Trans. 1980 Oct;8(5):631-2. doi: 10.1042/bst0080631.
4
[Enzyme deficiencies in glycolysis and nucleotide metabolism of red blood cells in nonspherocytic hemolytic anemia (author's transl)].非球形红细胞性溶血性贫血中红细胞糖酵解及核苷酸代谢的酶缺乏(作者译)
Klin Wochenschr. 1976 Sep 1;54(17):803-21. doi: 10.1007/BF01469302.
5
Characterization of cDNAs coding for glucose phosphate isomerase and phosphoglycerate kinase in Chinese hamster ovary cell line CHO-K1 and identification of defects in R1.1.7, a glycolysis-deficient variant of CHO-K1.中国仓鼠卵巢细胞系CHO-K1中编码葡萄糖磷酸异构酶和磷酸甘油酸激酶的cDNA的特性分析以及CHO-K1糖酵解缺陷变体R1.1.7中的缺陷鉴定。
Somat Cell Mol Genet. 1995 Jan;21(1):75-81. doi: 10.1007/BF02255824.
6
Complementation of metabolic defect in phosphoglycerate kinase (PGK)-deficient line of Chinese hamster ovary cells by introduction of human PGK cDNA.
Somat Cell Mol Genet. 1988 May;14(3):287-92. doi: 10.1007/BF01534589.
7
Properties of carbohydrate utilising variants of Chinese hamster cells.中国仓鼠细胞碳水化合物利用变体的特性
Cell Biol Int Rep. 1977 Nov;1(6):563-70. doi: 10.1016/0309-1651(77)90095-9.
8
Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity.对糖酵解缺陷细胞的研究表明,乳酸的产生并非肿瘤酸性的唯一原因。
Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):1127-31. doi: 10.1073/pnas.90.3.1127.
9
[Defects in erythrocyte glycolysis enzymes as the cause of nonspherocytic hemolytic anemia].[红细胞糖酵解酶缺陷作为非球形红细胞溶血性贫血的病因]
Z Gesamte Inn Med. 1976 May 1;31(9):257-61.
10
[On the regulation of the carbohydrate catabolism in the ischemic heart muscle of the dog].[关于犬缺血性心肌中碳水化合物分解代谢的调节]
Folia Haematol Int Mag Klin Morphol Blutforsch. 1968;89(4):496-500.

引用本文的文献

1
Transport and accumulation of 2-deoxy-D-glucose in wild-type and hexokinase-deficient cultured Chinese-hamster ovary (CHO) cells.2-脱氧-D-葡萄糖在野生型和己糖激酶缺陷型中国仓鼠卵巢(CHO)培养细胞中的转运与积累
Biochem J. 1989 May 15;260(1):153-5. doi: 10.1042/bj2600153.