du Bois R M, Townsend P J, Cole P J
Clin Exp Immunol. 1980 Apr;40(1):60-5.
Levels of the lysosomal enzyme N-acetyl-beta-glucosaminidase were measured in alveolar macrophage extracts and lung lavage fluid obtained from patients with cryptogenic fibrosing alveolitis and a control group. Evidence is presented which suggests that macrophages from patients with cryptogenic fibrosing alveolitis secrete this enzyme in vivo. To investigate one of the possible mechanisms of stimulating this secretion, an assessment was made of the C3b receptor sites on alveolar macrophages. While there were fewer receptor sites on the macrophages from patients with cryptogenic fibrosing alveolitis, which might indicate that they were occupied in vivo, this difference did not reach statistical significance. It is suggested that the alveolar macrophage is not merely a phagocyte but that it also has a more active role in the pathogenesis of cryptogenic fibrosing alveolitis.
在隐源性纤维性肺泡炎患者和对照组的肺泡巨噬细胞提取物及肺灌洗液中，检测了溶酶体酶N-乙酰-β-氨基葡萄糖苷酶的水平。有证据表明，隐源性纤维性肺泡炎患者的巨噬细胞在体内分泌这种酶。为了研究刺激这种分泌的一种可能机制，对肺泡巨噬细胞上的C3b受体位点进行了评估。虽然隐源性纤维性肺泡炎患者的巨噬细胞上的受体位点较少，这可能表明它们在体内已被占据，但这种差异未达到统计学意义。有人提出，肺泡巨噬细胞不仅是一种吞噬细胞，而且在隐源性纤维性肺泡炎的发病机制中也发挥着更积极的作用。
