甲状旁腺激素和醋酸脱氧皮质酮诱导的大鼠高血压
Parathyroid hormone- and deoxycorticosterone acetate-induced hypertension in the rat.
作者信息
Berthelot A, Gairard A
出版信息
Clin Sci (Lond). 1980 May;58(5):365-71. doi: 10.1042/cs0580365.
PMID:7389263
Abstract
- Hypertension induced by treatment with deoxycorticosterone acetate and sodium chloride was studied in male Sprague-Dawley rats and related to parathyroid hormone secretion. 2. Lack of parathyroid hormone (due to parathyroidectomy) or decreased parathormone secretion (due to a high-calcium diet) partially inhibited the development of arterial hypertension. 3. In contrast, in thyroparathyroidectomized rats supplemented with thyroxine, the administration of parathyroid hormone rapidly elevated arterial blood pressure. 4. Maintaining a physiological concentration of serum calcium in the absence of parathyroid hormone (by feeding a high-calcium diet to parathyroidectomized rats) was not sufficient to establish mineralocorticoid hypertension. 5. These results show that parathyroid hormone is necessary for the complete development of mineralocorticoid hypertension.
摘要
- 研究了用醋酸脱氧皮质酮和氯化钠治疗诱导的高血压在雄性斯普拉格 - 道利大鼠中的情况，并将其与甲状旁腺激素分泌相关联。2. 缺乏甲状旁腺激素（由于甲状旁腺切除术）或甲状旁腺激素分泌减少（由于高钙饮食）部分抑制了动脉高血压的发展。3. 相反，在补充甲状腺素的甲状腺甲状旁腺切除大鼠中，给予甲状旁腺激素会迅速升高动脉血压。4. 在没有甲状旁腺激素的情况下维持血清钙的生理浓度（通过给甲状旁腺切除的大鼠喂食高钙饮食）不足以引发盐皮质激素性高血压。5. 这些结果表明，甲状旁腺激素对于盐皮质激素性高血压的完全发展是必要的。
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Parathyroid hormone- and deoxycorticosterone acetate-induced hypertension in the rat.甲状旁腺激素和醋酸脱氧皮质酮诱导的大鼠高血压
Clin Sci (Lond). 1980 May;58(5):365-71. doi: 10.1042/cs0580365.
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Parathyroidectomy significantly decreases hypertension in spontaneously hypertensive and deoxycorticosterone plus saline treated rats.甲状旁腺切除术可显著降低自发性高血压大鼠以及接受脱氧皮质酮加生理盐水处理的大鼠的血压。
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引用本文的文献
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Parathyroidectomy ameliorates vascular lesions induced by deoxycorticosterone in the rat.甲状旁腺切除术可改善脱氧皮质酮诱导的大鼠血管病变。
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Raised plasma intact parathyroid hormone concentrations in young people with mildly raised blood pressure.血压轻度升高的年轻人血浆完整甲状旁腺激素浓度升高。
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