Bogoslovova T, Staneva D
Eksp Med Morfol. 1980;19(1):21-5.
The authors examined the activity of the enzyme phosphorilase in the myocardium of rats with spontaneous hypertension of the Okamoto Aoki type and of Wistar rats with experimental metacorticoid hypertension. They found higher basal activity of phosphorilase "a" in the both groups of hypertonic rats. After treatment of rats with isoprenaline in a dose of I mg/kg, administered intraperitonealy, the phosphorilase "a" in the myocardium of hypertensive animals was activated to a degree equal to that of the normotensive rats. This correlated also with the maximal isoprenaline chronotropic response in the both groups of hypertensive rats. The authors discussed the possible causes and mechanisms for the observed changes and effects.
作者研究了冈本青木型自发性高血压大鼠以及实验性促肾上腺皮质激素性高血压Wistar大鼠心肌中磷酸化酶的活性。他们发现两组高血压大鼠中磷酸化酶“a”的基础活性均较高。以1mg/kg的剂量腹腔注射异丙肾上腺素处理大鼠后，高血压动物心肌中的磷酸化酶“a”被激活到与正常血压大鼠相同的程度。这也与两组高血压大鼠对异丙肾上腺素的最大变时反应相关。作者讨论了观察到的变化和效应的可能原因及机制。
