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携带石棉的巨噬细胞中的蛋白质异常。

Protein abnormalities in macrophages bearing asbestos.

作者信息

Lemkin P, Lipkin L, Merril C, Shifrin S

出版信息

Environ Health Perspect. 1980 Feb;34:75-89. doi: 10.1289/ehp.803475.

DOI:10.1289/ehp.803475
PMID:7389689
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1568514/
Abstract

Computerized techniques for the evaluation of O'Farrell two-dimensional electrophoretic gels have been applied to proteins derived from asbestos bearing macrophages. Preliminary results indicate definite changes in the protein content of cells depending on fiber phagocytosis.

摘要

用于评估奥法雷尔二维电泳凝胶的计算机技术已应用于源自含石棉巨噬细胞的蛋白质。初步结果表明，根据纤维吞噬作用，细胞的蛋白质含量有明显变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/8f729bae1a0d/envhper00470-0092-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/a39fb06b0e61/envhper00470-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/bb7f2ec01a8d/envhper00470-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/c9df4e5e51bd/envhper00470-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/531c3318e84d/envhper00470-0081-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/80c824502506/envhper00470-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/4306d9dccb87/envhper00470-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b04d4905a91b/envhper00470-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b51bac6204df/envhper00470-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/39eb27294aba/envhper00470-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/fe3765fc97c4/envhper00470-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/ba2f64deb0d2/envhper00470-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/a14c1ee24e35/envhper00470-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/0735d2c17b87/envhper00470-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/594781efca59/envhper00470-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/27a06da57b5e/envhper00470-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/359ccf726801/envhper00470-0092-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b9ce5283584a/envhper00470-0092-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/8f729bae1a0d/envhper00470-0092-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/a39fb06b0e61/envhper00470-0080-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/bb7f2ec01a8d/envhper00470-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/c9df4e5e51bd/envhper00470-0081-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/531c3318e84d/envhper00470-0081-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/80c824502506/envhper00470-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/4306d9dccb87/envhper00470-0083-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b04d4905a91b/envhper00470-0083-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b51bac6204df/envhper00470-0084-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/39eb27294aba/envhper00470-0085-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/fe3765fc97c4/envhper00470-0086-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/ba2f64deb0d2/envhper00470-0086-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/a14c1ee24e35/envhper00470-0087-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/0735d2c17b87/envhper00470-0088-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/594781efca59/envhper00470-0088-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/27a06da57b5e/envhper00470-0092-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/359ccf726801/envhper00470-0092-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/b9ce5283584a/envhper00470-0092-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e22/1568514/8f729bae1a0d/envhper00470-0092-d.jpg

相似文献

1
Protein abnormalities in macrophages bearing asbestos.携带石棉的巨噬细胞中的蛋白质异常。
Environ Health Perspect. 1980 Feb;34:75-89. doi: 10.1289/ehp.803475.
2
Cytotoxic effect of asbestos on macrophages in different activation states.石棉对不同活化状态巨噬细胞的细胞毒性作用。
Environ Health Perspect. 1983 Sep;51:147-52. doi: 10.1289/ehp.8351147.
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Effect of asbestos on the P388D1 macrophagelike cell line: preliminary ultrastructural observations.石棉对P388D1巨噬样细胞系的影响：初步超微结构观察
Environ Health Perspect. 1983 Sep;51:109-17. doi: 10.1289/ehp.8351109.
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Production of nitric oxide elevates nitrosothiol formation resulting in decreased glutathione in macrophages exposed to asbestos or asbestos substitutes.一氧化氮的产生会提高亚硝基硫醇的形成，导致暴露于石棉或石棉替代品的巨噬细胞中谷胱甘肽减少。
Arch Toxicol. 2005 Feb;79(2):83-9. doi: 10.1007/s00204-004-0608-6. Epub 2004 Oct 15.
5
Identification of phagocytosis-associated surface proteins of macrophages by two-dimensional gel electrophoresis.通过二维凝胶电泳鉴定巨噬细胞吞噬作用相关的表面蛋白
J Cell Biol. 1982 Feb;92(2):283-8. doi: 10.1083/jcb.92.2.283.
6
Macrophage stimulation and the inflammatory response to asbestos.巨噬细胞刺激与对石棉的炎症反应。
Environ Health Perspect. 1980 Feb;34:69-74. doi: 10.1289/ehp.803469.
7
Asbestos cytotoxicity in a long term macrophage-like cell culture.长期巨噬细胞样细胞培养中的石棉细胞毒性
Nature. 1976 Dec 2;264(5585):444-6. doi: 10.1038/264444a0.
8
Role of reactive oxygen metabolites in crocidolite asbestos toxicity to mouse macrophages.活性氧代谢产物在青石棉对小鼠巨噬细胞毒性中的作用。
Cancer Res. 1986 Nov;46(11):5558-66.
9
Cytotoxicity of long and short crocidolite asbestos fibers in vitro and in vivo.长、短青石棉纤维的体内外细胞毒性
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Factors involved in the cytotoxicity of UICC amosite towards macrophages.国际抗癌联盟（UICC）铁石棉对巨噬细胞细胞毒性的相关因素。
Environ Health Perspect. 1983 Sep;51:245-8. doi: 10.1289/ehp.8351245.

本文引用的文献

1
A real time picture processor for use in biologic cell identification. II. Hardware implementation.
J Histochem Cytochem. 1974 Jul;22(7):732-40. doi: 10.1177/22.7.732.
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A real time picture processor for use in biologic cell identification. I. System design.
J Histochem Cytochem. 1974 Jul;22(7):725-31. doi: 10.1177/22.7.725.
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The in vivo effects of asbestos on macrophage membrane structure and population characteristics of macrophages: a scanning electron microscope study.石棉对巨噬细胞膜结构及巨噬细胞群体特征的体内效应：一项扫描电子显微镜研究。
J Reticuloendothel Soc. 1976 Aug;20(2):159-70.
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High resolution two-dimensional electrophoresis of proteins.蛋白质的高分辨率二维电泳
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