Barros D'Sa A A, Buchanan K D
Eur Surg Res. 1980;12(1):52-61. doi: 10.1159/000128109.
The objectives of the present work were to study the role (and possible sources) of gastrin and glucagon, as measured by radioimmunoassay techniques, in the acute response to massive bowel resection in dogs. Four acute experimental models were designed for this purpose. Circulating portal and arterial hormone concentrations were estimated under basal conditions and after administration of an intraduodenal fat stimulus. Stimulated portal gastrin levels were significantly higher in animals with bowel resections than in intact animals (p less than 0.05 to p less than 0.01) but the depletion of N-terminal glucagon-like (GLI) reactivity or total GLI was only transiently significant (p less than 0.05). Pancreatectomy, with or without resection, resulted in depletion of circulating N-terminal and C-terminal GLI, although not to zero values, suggesting extra-pancreatic sources of the GLI. Portal-arterial differences were noted for GLI but not for gastrin.
本研究的目的是通过放射免疫分析技术，研究胃泌素和胰高血糖素在犬大肠大部切除急性反应中的作用（以及可能的来源）。为此设计了四种急性实验模型。在基础条件下以及给予十二指肠内脂肪刺激后，估计门静脉和动脉血中激素浓度。肠切除动物的刺激后门静脉胃泌素水平显著高于完整动物（p小于0.05至p小于0.01），但N端胰高血糖素样（GLI）反应性或总GLI的减少仅短暂显著（p小于0.05）。无论有无肠切除，胰腺切除均导致循环中N端和C端GLI减少，尽管未降至零值，提示GLI有胰腺外来源。GLI存在门静脉-动脉差异，但胃泌素不存在。
