Yoshimasu F, Yasui M, Yase Y, Iwata S, Gajdusek D C, Gibbs C J, Chen K M
Folia Psychiatr Neurol Jpn. 1980;34(1):75-82. doi: 10.1111/j.1440-1819.1980.tb01515.x.
Metal analysis of calcium, manganese, aluminum and copper in CNS tissue samples of degenerative CNS disease cases (six Japanese ALS, three Japanese Alzheimer disease, four Guam PD, one Guam ALS) using neutron activation analysis, was conducted with following results: Five of six Japanese ALS cases, two of three Japanese Alzheimer disease cases and all of four Guam PD cases showed a high content of calcium and aluminum in CNS tissue with a significant positive correlation between calcium and aluminum and/or between calcium and manganese. These findings suggest a possible process of metal-induced soft tissue calcification with interaction of other di- and/or trivalent cations such as aluminum, manganese in CNS tissue of these degenerative CNS diseases.
利用中子活化分析对退行性中枢神经系统疾病病例（6例日本肌萎缩侧索硬化症、3例日本阿尔茨海默病、4例关岛帕金森病、1例关岛肌萎缩侧索硬化症）的中枢神经系统组织样本中的钙、锰、铝和铜进行金属分析，结果如下：6例日本肌萎缩侧索硬化症病例中的5例、3例日本阿尔茨海默病病例中的2例以及所有4例关岛帕金森病病例的中枢神经系统组织中钙和铝含量较高，钙与铝和/或钙与锰之间存在显著正相关。这些发现表明，在这些退行性中枢神经系统疾病的中枢神经系统组织中，金属诱导的软组织钙化可能与铝、锰等其他二价和/或三价阳离子相互作用有关。
