Maraschio P, Zuffardi O, Lo Curto F
Hum Genet. 1980;54(2):265-7. doi: 10.1007/BF00278982.
The Cd technique was applied to two cases of dicentric attached X chromosomes (XpXp and XqXq) and to cells from an established cell line of tumor origin (MaNo9) in which dicentrics with two active centromeres were present and dicentrics with one active and one inactive centromere. It was confirmed that the Cd technique discriminates between active and latent centromeres, and it was demonstrated that true dicentrics and dicentrics with one latent centromere can co-exist in the same cells. This indicates that the mechanism of centromere inactivation is a phenomenon that is specific to each chromosome and not generalized at the level of the individual cell.
镉技术应用于两例双着丝粒附着X染色体（XpXp和XqXq）以及来自一个已建立的肿瘤源细胞系（MaNo9）的细胞，该细胞系中存在具有两个活性着丝粒的双着丝粒以及一个活性着丝粒和一个非活性着丝粒的双着丝粒。已证实镉技术能够区分活性着丝粒和潜在着丝粒，并且证明真正的双着丝粒和具有一个潜在着丝粒的双着丝粒可以共存于同一细胞中。这表明着丝粒失活机制是一种特定于每条染色体的现象，而非在单个细胞水平上普遍存在。
