Roszkowski W, Wrembel J K, Roszkowski K, Janiak M, Szmigielski S
Int J Cancer. 1980 Feb 15;25(2):289-92. doi: 10.1002/ijc.2910250218.
The effect of micro-wave whole-body hyperthermia on tumor growth and lung metastasis counts was examined in adult BALB/c mice. The effective therapy with hyperthermia prolonging mean survival time of the animals and causing tumor regression resulted in concimitant depression of anti-tumor immunity measured in vivo. The beneficial effect of preimmunization of animals with killed tumor cells on subsequent challenge with live tumor cells was completely abrogated by hyperthermia treatment. It is postulated that this form of therapy is directly related only to heat sensitivity of tumor cells and that there is no profitable participation of the immune system in the anti-tumor effect of wholebody hyperthermia.
在成年BALB/c小鼠中研究了微波全身热疗对肿瘤生长和肺转移灶数量的影响。热疗的有效治疗延长了动物的平均生存时间并导致肿瘤消退，同时在体内测量的抗肿瘤免疫力受到抑制。用灭活肿瘤细胞对动物进行预免疫对随后用活肿瘤细胞进行攻击的有益效果被热疗完全消除。据推测，这种治疗形式仅与肿瘤细胞的热敏感性直接相关，并且免疫系统在全身热疗的抗肿瘤作用中没有有益的参与。
