de Brux J, Trévoux R, Willemin A
J Gynecol Obstet Biol Reprod (Paris). 1978 May-Jun;7(5):945-51.
The discovery of carcinomatous cells in a discharge from a breast, without any other clinical, mammographic or thermographic sign, allowed the removal of a carcinoma in its pre-clinical stage. The histological study in a series of cuts showed a carcinoma that was still intraductal and which showed signs of cellular regression accompanied by marked peri-canalicular sclerosis associated with inflammatory infiltration. This observation allows commentaries to be made concerning the immunological process that goes with carcinoma in its intra-epithelial stage and permits the possibility of predicting an advance in the understanding and treatment of carcinomata which should be diagnosed very early.