Serov V V, Zolotarevskiĭ V B
Arkh Patol. 1979;41(1):3-11.
True early forms of mammary cancer include tumours undetectable in routine clinical examinations and histologically presenting intraductal and lobular cancer (cancer in situ and with beginning invasion) in the absence of metastases. Parallel histological and cytological examinations and cytospectrophotometric determination of the DNA content increase the validity of the differential diagnosis between benign displasias and carcinoma in situ. Stages of composite clinico-roentgenilogical and morphological diagnosis of early mammary cancer have been developed. Two mammographic signs: accumulations of finest calcinates and filamentous tumour node less than 10 mm in diameter, permit to diagnose clinically latent cancer which has two forms of growth, diffuse and nodular. The diffuse form in some cases presents a stage preceeding the nodular form.
真正早期的乳腺癌包括在常规临床检查中无法检测到的肿瘤，组织学上表现为导管内癌和小叶癌（原位癌及伴有早期浸润）且无转移。并行的组织学和细胞学检查以及DNA含量的细胞分光光度测定提高了良性发育异常与原位癌鉴别诊断的准确性。已制定了早期乳腺癌综合临床-放射学和形态学诊断的分期。两种乳房X线摄影征象：最细微的钙化聚集和直径小于10毫米的丝状肿瘤结节，有助于诊断具有两种生长形式（弥漫性和结节性）的临床隐匿性癌。在某些情况下，弥漫性形式呈现为结节性形式之前的一个阶段。
