Barrat J, Léger D
J Gynecol Obstet Biol Reprod (Paris). 1979 Jun;8(4):333-42.
Some geneticists have been against induction of ovulation because there is a greater incidence of chromosome abnormalities in spontaneous abortions that occur after induced pregnancies. We have found the number of early abortions (15.6 p. 100) and of malformed fetuses (4.8 p. 100) is not greater than average when we have studied a personal prospective series of 140 pregnancies and a series of 519 pregnancies collected following an enquiry made among some of our colleagues. The number of late abortions and of premature labours is much higher (3.4 p. 100 and 14.8 p. 100 respectively) and they correspond particularly with the higher incidence of multiple pregnancies (12.3 p. 100) which have been obtained especially after the use of HMG. This has a direct repercussion on perinatal mortality (4.3 p. 100).
一些遗传学家反对诱导排卵，因为在诱导妊娠后发生的自然流产中，染色体异常的发生率更高。在研究了我们个人的140例妊娠前瞻性系列以及在向一些同事进行调查后收集的519例妊娠系列后，我们发现早期流产（15.6‰）和畸形胎儿（4.8‰）的数量并不高于平均水平。晚期流产和早产的数量要高得多（分别为3.4‰和14.8‰），它们尤其与多胎妊娠的较高发生率（12.3‰）相对应，多胎妊娠尤其在使用人绝经期促性腺激素（HMG）后出现。这对围产期死亡率有直接影响（4.3‰）。
