James O, Mayes R W, Stevenson C J
Lancet. 1977 Dec 10;2(8050):1217-9. doi: 10.1016/s0140-6736(77)90451-2.
Vitiligo, morphologically indistinguishable from true vitiligo, was detected in 54 of 198 men exposed to p-tert-butylphenol (P.T.B.P.) during its manufacture. There is evidence that P.T.B.P. caused vitiligo by a systemic mechanism and that the severity of the disease was related to the intensity of exposure. No association with autoimmune disease was found. Screening for other possible associated disorders revealed mildly abnormal liver-function tests in 6 workers: liver biopsy confirmed liver damage. Of the 144 men exposed to P.T.B.P. who did not have vitiligo, only 2 had any abnormal liver-function tests. It seems possible that the liver damage is related to P.T.B.P.
在198名对叔丁基苯酚（P.T.B.P.）生产过程中接触过该物质的男性中，发现54人患有形态上与真性白癜风无法区分的白癜风。有证据表明，P.T.B.P. 通过一种全身性机制导致白癜风，且疾病的严重程度与接触强度有关。未发现与自身免疫性疾病有关联。对其他可能相关疾病的筛查发现，6名工人的肝功能检查轻度异常：肝脏活检证实有肝损伤。在144名接触过P.T.B.P. 但未患白癜风的男性中，只有2人肝功能检查有任何异常。肝损伤似乎有可能与P.T.B.P. 有关。
