MacGregor R R, Gluckman S J, Senior J R
J Infect Dis. 1978 Dec;138(6):747-55. doi: 10.1093/infdis/138.6.747.
Chronic alcoholics who had been drinking heavily until admission for withdrawal from alcohol were studied to determine their level of granulocyte function, immunoglobulin concentration, and complement system activity. Although most had some mild derangement in results of liver function tests, serum albumin concentrations were normal, and there was no clinical evidence of malnutrition or cirrhosis. Granulocyte adherence was slightly depressed in two subjects (52.4% and 54.1%; normal, 76.0% +/- 12%), although mean adherence for the group was normal. Mean chemotaxis was significantly below normal (2,103 vs. 7,943 counts per min), and the impairment was related to a defect or inhibitor in the serum of patients. Phagocytic activity was less than half that of control subjects in two alcoholics, but mean values were not depressed. Bactericidal activity was normal in all. Serum concentrations of immunoglobulins and total hemolytic complement activity were above the normal range for the group. The general inhibition of chemotaxis or the occasional defects in other granulocyte functions may contribute to the difficulty that alcoholics have with infection.
对那些在入院接受戒酒治疗前一直大量饮酒的慢性酗酒者进行了研究，以确定他们的粒细胞功能水平、免疫球蛋白浓度和补体系统活性。尽管大多数人肝功能测试结果有一些轻微紊乱，但血清白蛋白浓度正常，且没有营养不良或肝硬化的临床证据。两名受试者的粒细胞黏附略有降低（分别为52.4%和54.1%；正常为76.0%±12%），尽管该组的平均黏附正常。平均趋化性显著低于正常水平（每分钟2103个细胞对7943个细胞），这种损害与患者血清中的缺陷或抑制剂有关。两名酗酒者的吞噬活性不到对照受试者的一半，但平均值未降低。所有人的杀菌活性均正常。该组免疫球蛋白的血清浓度和总溶血补体活性高于正常范围。趋化性的普遍抑制或其他粒细胞功能偶尔出现的缺陷可能是酗酒者易感染的原因。
