Onishi S, Saibara T, Maeda T, Yamamoto Y, Ito K
First Department of Internal Medicine, Kochi Medical School, Japan.
Gastroenterol Jpn. 1989 Jun;24(3):284-9. doi: 10.1007/BF02774326.
Serum inhibition of complement-derived leukocyte chemotaxis was examined in alcoholic liver disease with or without cirrhosis. Chemotactic inhibitory activity (CIA) was detected with higher frequency and degree in alcoholic liver disease, especially with liver cirrhosis compared with normal subjects and non-alcoholic liver cirrhosis. CIA was found in anti-IgA adsorbed fractions in the sera of patients with alcoholic liver cirrhosis. Serum concentrations of IgA1 and IgA2 in alcoholic liver disease were statistically higher than in non-alcoholic liver cirrhosis. However, no correlation between CIA and the concentrations of IgA subclasses was demonstrated in alcoholic liver disease. This serum inhibitor may partly explain the high susceptibility to bacterial infection in alcoholic liver disease.
在伴有或不伴有肝硬化的酒精性肝病患者中检测了血清对补体衍生的白细胞趋化性的抑制作用。与正常受试者和非酒精性肝硬化患者相比，酒精性肝病患者中趋化抑制活性（CIA）的检出频率和程度更高，尤其是肝硬化患者。在酒精性肝硬化患者血清中抗IgA吸附组分中发现了CIA。酒精性肝病患者血清中IgA1和IgA2的浓度在统计学上高于非酒精性肝硬化患者。然而，在酒精性肝病中未发现CIA与IgA亚类浓度之间存在相关性。这种血清抑制剂可能部分解释了酒精性肝病患者对细菌感染的高度易感性。
