Bogdal J, Cichecka K, Kirchmayer S, Mika M, Tarnawski A
Arch Immunol Ther Exp (Warsz). 1976;24(6):799-805.
Serum immunoglobulin levels and alpha1-fetoprotein were measured in 49 male alcoholics entering an abstinence program. These parameters were evaluated in relation to liver histology. Of 49 studied alcoholics, 32 had elevated serum immunoglobulin levels, chiefly IgA, which occurred in 29 patients. IgA elevation was also observed in patients with normal histological picture of the liver. Of 17 alcoholics with normal immunoglobulin levels, in 9, i.e. 53%, liver histology was normal. In the group of 32 alcoholics with elevated immunoglobulin levles, normal liver histology was encountered only in 8 patients, i.e. 25%. Two-month abstinence in 18 alcoholics with previously elevated IgA levels caused their decrease in 12 patients, i.e. 66%. A decrease in IgA was noted even in patients with symptoms of histological worsening. Of 49 alcoholics, only 1 showed significantly elevated alpha1-fetoprotein.
对49名进入戒酒项目的男性酗酒者测定了血清免疫球蛋白水平和甲胎蛋白。这些参数与肝脏组织学相关联进行了评估。在49名接受研究的酗酒者中，32人的血清免疫球蛋白水平升高，主要是IgA升高，有29名患者出现这种情况。在肝脏组织学图像正常的患者中也观察到了IgA升高。在17名免疫球蛋白水平正常的酗酒者中，有9人（即53%）肝脏组织学正常。在免疫球蛋白水平升高的32名酗酒者组中，只有8名患者（即25%）肝脏组织学正常。18名之前IgA水平升高的酗酒者戒酒两个月后，12名患者（即66%）的IgA水平下降。即使在有组织学恶化症状的患者中也注意到了IgA的下降。49名酗酒者中只有1人的甲胎蛋白显著升高。
