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Inhibition of exogenous mRNA translation in a cell-free system by chromatin peptides from calf thymus.

作者信息

Gianfranceschi G L, Hillar M, Przyjemski J, Amici D, Guglielmi L

出版信息

Mol Biol Rep. 1980 Mar 31;6(1):27-9. doi: 10.1007/BF00775750.

DOI:10.1007/BF00775750
PMID:7393223
Abstract

Low molecular weight chromatin peptides isolated from calf thymus by affinity chromatography on DNA-cellulose inhibit significantly translation of exogenous isolated mRNA in a reticulocyte cell-free system. Translation with endogenous mRNA present in the system is not inhibited by low peptide concentrations. The data obtained combined with the previous findings suggest that chromatin peptides control gene expression at two levels: transcription and translation.

摘要

相似文献

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引用本文的文献

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Studies on nuclear deprimerones: isolation, fractionation, characterization and control of gene expression.
Mol Biol Rep. 1980 Oct 31;6(3):169-77. doi: 10.1007/BF00775412.

本文引用的文献

1
Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.小牛胸腺中存在一种在体外控制DNA转录的肽因子的证据。
Biochim Biophys Acta. 1975 Nov 18;414(1):9-19. doi: 10.1016/0005-2787(75)90121-5.
2
Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus.
Mol Biol Rep. 1976 Sep;3(1):55-64. doi: 10.1007/BF00357209.
3
Restriction of template capacity of rat liver chromatin by a non-histone peptide from calf thymus.
Nature. 1976 Aug 12;262(5569):622-3. doi: 10.1038/262622a0.
4
An efficient mRNA-dependent translation system from reticulocyte lysates.一种来自网织红细胞裂解物的高效mRNA依赖性翻译系统。
Eur J Biochem. 1976 Aug 1;67(1):247-56. doi: 10.1111/j.1432-1033.1976.tb10656.x.
5
Low molecular weight peptides controlling transcription are present in the calf thymus chromatin structure.
Mol Biol Rep. 1977 Dec;3(6):429-36. doi: 10.1007/BF00808384.
6
Control of transcription and translation by low molecular weight peptides (deprimerones) from chromatin and poly(A)-messenger RNA. Implication in the mechanism of carcinogenesis.
Biochim Biophys Acta. 1979 Sep 27;564(2):246-63. doi: 10.1016/0005-2787(79)90223-5.
7
Low-molecular-weight peptide inhibits RNA synthesis in human leukemic and phytohemagglutinin-stimulated leukocytes and globin mRNA transcription in differentiating Friend cells.低分子量肽可抑制人白血病细胞及植物血凝素刺激的白细胞中的RNA合成，以及分化中的Friend细胞中的珠蛋白mRNA转录。
Proc Natl Acad Sci U S A. 1977 Sep;74(9):3869-73. doi: 10.1073/pnas.74.9.3869.