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Low molecular weight peptides controlling transcription are present in the calf thymus chromatin structure.

作者信息

Gianfranceschi G L, Guglielmi L, Amici D, Bossa F, Barra D, Petruzzelli R

出版信息

Mol Biol Rep. 1977 Dec;3(6):429-36. doi: 10.1007/BF00808384.

DOI:10.1007/BF00808384
PMID:593273
Abstract

A calf thymus peptide fraction controlling DNA and chromatin template has been purified by DNA-cellulose and Dowex 50 WX2 chromatography and its amino acid composition determined. The active peptide fraction can be extracted in high pH buffer from calf thymus native chromatin previously deproteinized by chloroform-isamyl alcohol and phenol. These data demonstrate that the thymic peptide(s) is (are) a chromatin protein constituent strongly linked to DNA. The specificity in association of the peptide(s) to DNA has also been considered.

摘要

相似文献

1
Low molecular weight peptides controlling transcription are present in the calf thymus chromatin structure.
Mol Biol Rep. 1977 Dec;3(6):429-36. doi: 10.1007/BF00808384.
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Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.小牛胸腺中存在一种在体外控制DNA转录的肽因子的证据。
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[Studies on thymic peptide factors. II. Biochemical characterization of calf thymic peptide factors].
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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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The preparation of deoxyribonucleic acids by the p-aminosalicylate-phenol method.用对氨基水杨酸盐-苯酚法制备脱氧核糖核酸
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Control of RNA and protein synthesis in phytohemagglutinin-stimulated human lymphocytes by chromatin peptides from calf thymus.
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Purification of a DNA polymerase from calf thymus nuclei.从小牛胸腺细胞核中纯化一种DNA聚合酶。
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Tissue-specific transcription of the globin gene in isolated chromatin.分离染色质中珠蛋白基因的组织特异性转录。
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Evidence for the presence in calf thymus of a peptidic factor controlling DNA transcription in vitro.小牛胸腺中存在一种在体外控制DNA转录的肽因子的证据。
Biochim Biophys Acta. 1975 Nov 18;414(1):9-19. doi: 10.1016/0005-2787(75)90121-5.
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Stabilization of double-stranded DNA molecule by non-histone peptidic effector from calf thymus.
Mol Biol Rep. 1976 Sep;3(1):55-64. doi: 10.1007/BF00357209.
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Restriction of template capacity of rat liver chromatin by a non-histone peptide from calf thymus.
Nature. 1976 Aug 12;262(5569):622-3. doi: 10.1038/262622a0.