Root T E, Edwards L D, Spengler P J
Sex Transm Dis. 1980 Apr-Jun;7(2):59-65.
The clinical and laboratory features of nongonococcal urethritis were studied in 96 patients. Data from previous episodes of urethritis were obtained from 88 men; histories of previous urethritis were obtained from 46 (52%) of the 88 men. Prostatic enlargement (and often tenderness) was found on rectal examination of 22 men (23%) and correlated with a history of previous episodes(s) of urethritis (P less than 0.01). Chlamydia trachomatis was recovered from 19 patients (20%), Ureaplasma urealyticum from 58 (60%), and neither organism from 27 (28%). Results of serologic test for C. trachomatis correlated with cultural findings and demonstrated a high prevalence of preexisting antibody. In comparison with those patients whose urethral smears showed greater purulence, patients with five or fewer polymorphonuclear leukocytes (per 1,000 x field) on the urethral smear had similar frequencies of recovery of C. trachomatis, prostatic abnormalities, and responses to therapy, but had lower frequencies of urethral discharge and recovery of U. urealyticum. A 14-day course of either tetracycline hydrochloride or doxycycline hyclate was successful in eradicating both symptoms and pathogens, except for cases for cases in which initial isolates of U. urealyticum showed in-vitro resistance.
对96例非淋菌性尿道炎患者的临床和实验室特征进行了研究。88名男性提供了既往尿道炎发作的数据；88名男性中有46名（52%）有既往尿道炎病史。22名男性（23%）直肠指检发现前列腺肿大（常伴有压痛），且与既往尿道炎发作史相关（P<0.01）。19例患者（20%）分离出沙眼衣原体，58例（60%）分离出解脲脲原体，27例（28%）未分离出任何一种病原体。沙眼衣原体血清学检测结果与培养结果相关，显示既往抗体的高流行率。与尿道涂片脓性分泌物较多的患者相比，尿道涂片多形核白细胞（每高倍视野）少于5个的患者，沙眼衣原体分离率、前列腺异常情况及对治疗的反应频率相似，但尿道分泌物和解脲脲原体分离率较低。除最初分离的解脲脲原体显示体外耐药的病例外，盐酸四环素或盐酸多西环素14天疗程成功消除了症状和病原体。
