Epps D E, Natarajan V, Schmid P C, Schmid H O
Biochim Biophys Acta. 1980 Jun 23;618(3):420-30. doi: 10.1016/0005-2760(80)90260-x.
A new phospholipid was detected in the infarcted areas of canine myocardium 24 h after ligation of the left descending branch of the coronary artery. Both the central and peripheral areas of the infarct contained significant amounts of this lipid (4-6& of lipid phosphorus), but it was not present in the apparently normal portions of the same tissue. The lipid was isolated and characterized by its infrared spectrum, by chemical degradation and by comparison with synthetic and semi-synthetic standards. It was identified as a mixture of N-acylethanolamine glycerophospholipids consisting of diacyl-, alk-1-enylacyl- and alkylacylglycerol species. The N-acyl groups were mainly 16 : 0 and 18 : 0 with smaller proportions of 18 : 1 and 18 : 2. The relative decrease of ethanolamine glycerophospholipids in the infarcated areas and the similarity in their molecular species suggests a percursor-product relationship between these phospholipids.
在冠状动脉左降支结扎24小时后的犬心肌梗死区域检测到一种新的磷脂。梗死灶的中央和周边区域均含有大量这种脂质（占脂质磷的4 - 6%），但在同一组织的看似正常的部分中不存在。通过红外光谱、化学降解以及与合成和半合成标准品进行比较，对该脂质进行了分离和表征。它被鉴定为N - 酰基乙醇胺甘油磷脂的混合物，由二酰基、烯基 - 1 - 酰基和烷基酰基甘油种类组成。N - 酰基主要为16 : 0和18 : 0，18 : 1和18 : 2的比例较小。梗死区域中乙醇胺甘油磷脂的相对减少及其分子种类的相似性表明这些磷脂之间存在前体 - 产物关系。
