Natarajan V, Reddy P V, Schmid P C, Schmid H H
Biochim Biophys Acta. 1981 May 22;664(2):445-8. doi: 10.1016/0005-2760(81)90067-9.
Minced tissues from both infarcted and apparently normal areas of canine myocardium 6 h after ligation of the left descending branch of the coronary artery were incubated with [1,2-(14)C]ethanolamine. In each case substantial amounts of radioactivity were incorporated into both phosphatidylethanolamine and N-acylphosphatidylethanolamine. Incubation of homogenates from the same tissues with N-[1-(14)C]palmitoyl phosphatidylethanolamine yielded labeled N-palmitoyl ethanolamine. The data support the concept that N-acylethanolamines, pharmacologically active compounds which accumulate in infarcted myocardium, are produced by N-acylation of ethanolamine phospholipids followed by phosphodiesterase action.
在冠状动脉左前降支结扎6小时后，从犬心肌梗死区和外观正常区域获取的切碎组织与[1,2-(14)C]乙醇胺一起孵育。在每种情况下，大量放射性都掺入到磷脂酰乙醇胺和N-酰基磷脂酰乙醇胺中。用N-[1-(14)C]棕榈酰磷脂酰乙醇胺孵育相同组织的匀浆，产生标记的N-棕榈酰乙醇胺。这些数据支持这样的概念，即N-酰基乙醇胺是在梗死心肌中积累的药理活性化合物，它是由乙醇胺磷脂的N-酰化作用，然后经磷酸二酯酶作用产生的。
