育亨宾对去脑大鼠中肾上腺素的哌唑嗪抵抗性升压作用的阻断。
Blockage by yohimbine of prazosin-resistant pressor effects of adrenaline in the pithed rat.
作者信息
Flavahan N A, McGrath J C
出版信息
Br J Pharmacol. 1980 Jul;69(3):355-7. doi: 10.1111/j.1476-5381.1980.tb07021.x.
Abstract
In the pithed rat, following beta-adrenoceptor blockade, the pressor effect of adrenaline can be blocked by phentolamine or by prazosin plus yohimbine but not by prazosin or yohimbine given alone. It is concluded that adrenaline produces its pressor effect by acting on two sets of post-junctional alpha-adrenoceptors, each of which is sensitive to phentolamine, one of which is sensitive to prazosin but resistant to yohimbine and the other of which is sensitive to yohimbine but resistant to prazosin.
摘要
在脊髓横断的大鼠中，β-肾上腺素受体被阻断后，肾上腺素的升压作用可被酚妥拉明或哌唑嗪加育亨宾阻断，但单独给予哌唑嗪或育亨宾则不能阻断。结论是，肾上腺素通过作用于两组节后α-肾上腺素受体产生其升压作用，每组受体对酚妥拉明敏感，其中一组对哌唑嗪敏感但对育亨宾有抗性，另一组对育亨宾敏感但对哌唑嗪有抗性。
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