对影响大鼠心脏交感神经节α-肾上腺素能受体反馈的一些因素的分析。
An analysis of some factors influencing alpha-adrenoceptor feed-back at the sympathetic junction in the rat heart.
作者信息
Docherty J R, McGrath J C
出版信息
Br J Pharmacol. 1979 May;66(1):55-63. doi: 10.1111/j.1476-5381.1979.tb16097.x.
Abstract
1 The effects of the selective prejunctional alpha-adrenoceptor antagonist, yohimbine, on the cardioacceleration responses to sympathetic stimulation were examined in the pithed rat. 2 Yohimbine reversed the inhibitory effects of the alpha-adrenoceptor agonist, clonidine, on the stimulation-induced tachycardia. 3 Yohimbine failed to potentiate significantly responses to stimulation in the absence of clonidine when stimulation was applied at the optimal level for cardiac responses (C6-T1). 4 When the pithing rod electrode was moved to T2-T6, cardioaccelerator responses were smaller and yohimbine produced potentiation at frequencies of greater than or equal to 1 Hz. This potentiation was prejunctional since responses to exogenous noradrenaline (NA) were not increased by yohimbine. 5 In the presence of cocaine, potentiation by yohimbine could be shown at the lower frequency of 0.1 Hz. 6 The possible physiological significance of a negative feed-back effect of noradrenaline on cardiac sympathetic nerves is discussed.
摘要
- 在脊髓毁损大鼠中研究了选择性突触前α-肾上腺素能受体拮抗剂育亨宾对交感神经刺激所致心脏加速反应的影响。2. 育亨宾逆转了α-肾上腺素能受体激动剂可乐定对刺激诱导的心动过速的抑制作用。3. 当在心脏反应的最佳水平（C6-T1）施加刺激时，在无可乐定的情况下，育亨宾未能显著增强对刺激的反应。4. 当脊髓毁损棒电极移至T2-T6时，心脏加速反应较小，且育亨宾在大于或等于1Hz的频率下产生增强作用。这种增强作用是突触前的，因为育亨宾并未增加对外源性去甲肾上腺素（NA）的反应。5. 在可卡因存在的情况下，育亨宾在0.1Hz的较低频率下可表现出增强作用。6. 讨论了去甲肾上腺素对心脏交感神经负反馈作用的可能生理意义。
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Blood pressure and heart rate responses evoked by d- and l-amphetamine in the pithed rat preparation.去大脑大鼠制备中d-和l-苯丙胺诱发的血压和心率反应。
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Sympathomimetic effects of pancuronium bromide on the cardiovascular system of the pithed rat: a comparison with the effects of drugs blocking the neuronal uptake of noradrenaline.泮库溴铵对去脑大鼠心血管系统的拟交感神经效应：与去甲肾上腺素神经元摄取阻断药物效应的比较
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