Pumo D E, Gootnick D, Little B W, Chiu J F
Cancer Lett. 1980 Jun;9(4):285-91. doi: 10.1016/0304-3835(80)90019-1.
Tumor specific nuclear antigen was demonstrated in early stages of chemically-induced colon carcinogenesis. At these early stages, there is no observable nuclear or cytoplasmic alteration in the colon mucosae. The rise in tumor specific nuclear antigen in carcinogen-treated animals can be abolished by simultaneous treatment with carcinogen inhibitor. The potential for tumor specific nuclear antigen to be used as a pretumor diagnostic probe is discussed.
肿瘤特异性核抗原在化学诱导的结肠癌发生早期即可被检测到。在这些早期阶段，结肠黏膜中未观察到细胞核或细胞质的改变。用致癌物抑制剂同时处理可消除致癌物处理动物体内肿瘤特异性核抗原的升高。本文讨论了肿瘤特异性核抗原用作肿瘤前诊断探针的潜力。
