Olszewski W L, Kupiec-Weglinski J
Lymphology. 1978 Dec;11(4):222-30.
Total body distribution of IUDR labeled thoracic duct, mesenteric and peripheral lymph node blasts was investigated, after i.v. injection into normal syngeneic rats. Donors of immunoblasts were stimulated with SRBC 1 week before transfer of cells. Lymphoblasts, irrespective of the source of origin, accumulated preferentially in small intestine, lungs, skin and muscles. There was an evident difference in the whole body distribution pattern of injected thoracic duct and lymph node blasts, what points to the different behaviour of normally circulating immunoblasts. Only minor differences in distribution kinetics and sites of accumulation were found between mesenteric and peripheral blast cells. We put forward a hypothesis that immunoblasts behave like effector cells and their preferential localization in small gut, lungs, and skin may be mediated by antigens "physiologically" present on the surgace of tissue with direct contact with the external environment.
将碘脱氧尿苷（IUDR）标记的胸导管、肠系膜和外周淋巴结母细胞静脉注射到正常同基因大鼠体内后，研究了其在全身的分布情况。在细胞转移前1周，用绵羊红细胞（SRBC）刺激免疫母细胞供体。无论来源如何，淋巴母细胞都优先聚集在小肠、肺、皮肤和肌肉中。注射的胸导管和淋巴结母细胞在全身的分布模式存在明显差异，这表明正常循环的免疫母细胞行为不同。肠系膜和外周母细胞在分布动力学和聚集部位仅存在微小差异。我们提出一个假设，即免疫母细胞表现得像效应细胞，它们在小肠、肺和皮肤中的优先定位可能由与外部环境直接接触的组织表面“生理”存在的抗原介导。
