接触致敏过程中淋巴细胞黏附性的变化。
Changes in lymphocyte adhesiveness during contact sensitization.
作者信息
Kellie S, Evans C W
出版信息
Br J Exp Pathol. 1981 Apr;62(2):158-64.
Lymphoid cells from the draining lymph nodes of mice 3 days after oxazolone application were found to be more adhesive to each other and to glass than cells from unsensitized nodes. Examination of the temporal sequence of changes during contact sensitization showed that during the first 4 days after oxazolone application there was an increase in both the cellularity of the draining node and in the intercellular adhesiveness of cells from the draining node, which persisted for at least 14 days. There was also an increase in the lymphoblast content; however, this was transient, peaking at Day 4 before returning almost to normal by Day 7. The intercellular adhesiveness of a lymphoblast-enriched subpopulation from the draining node was greater than the adhesiveness of a small lymphocyte subpopulation from the same node. However, the adhesiveness of both these subpopulations were greater than that of normal, unsensitized lymphoid cells. The implications of a change in cellular adhesiveness on the migratory properties in vivo of lymphocytes are discussed.
在应用恶唑酮3天后，发现来自小鼠引流淋巴结的淋巴细胞比未致敏淋巴结的细胞彼此之间以及与玻璃的黏附性更强。对接触性致敏过程中变化的时间顺序进行检查发现，在应用恶唑酮后的前4天，引流淋巴结的细胞数量和引流淋巴结细胞的细胞间黏附性均增加，这种情况持续至少14天。淋巴母细胞含量也增加；然而，这是短暂的，在第4天达到峰值，到第7天几乎恢复正常。来自引流淋巴结的富含淋巴母细胞的亚群的细胞间黏附性大于来自同一淋巴结的小淋巴细胞亚群的黏附性。然而，这两个亚群的黏附性均大于正常的、未致敏的淋巴细胞的黏附性。文中讨论了细胞黏附性变化对淋巴细胞体内迁移特性的影响。
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