老年人中的亚二倍体与血清免疫球蛋白浓度

Hypodiploidy and serum immunoglobulin concentrations in the elderly.

作者信息

Matsuyama S S, Cohen D, Jarvik L F

出版信息

Mech Ageing Dev. 1978 Dec;8(6):407-12. doi: 10.1016/0047-6374(78)90039-8.

Abstract

Chromosome analyses and Ig level determinations were carried out on seventeen aged men and women, 83--100 years of age. In men, significant correlations were found between hypodiploidy and IgA (gamma = 0.95) and between monosomy C and IgG (gamma = 0.79) while in women, monosomy G and IgG were significantly correlated (gamma = 0.73). The emergence of significant correlations between chromosome loss and Ig levels in this study provides support for a relationship between age-associated chromosomal changes in T cells and the immunologic response of B cells.

摘要

对17名年龄在83至100岁之间的老年男性和女性进行了染色体分析和免疫球蛋白水平测定。在男性中，发现亚二倍体与IgA之间存在显著相关性（γ = 0.95），C单体与IgG之间存在显著相关性（γ = 0.79）；而在女性中，G单体与IgG存在显著相关性（γ = 0.73）。本研究中染色体缺失与免疫球蛋白水平之间出现的显著相关性，为T细胞中与年龄相关的染色体变化和B细胞的免疫反应之间的关系提供了支持。