免疫球蛋白与X染色体。
Immunoglobulins and the X-chromosome.
作者信息
Rhodes K, Markham R L, Maxwell P M, Monk-Jones M E
出版信息
Br Med J. 1969 Aug 23;3(5668):439-41. doi: 10.1136/bmj.3.5668.439.
Abstract
Serum levels of immunoglobulins (Ig) G, M, and A were determined in 28 women with an additional X-chromosome (XXX), and in equal numbers of age-matched normal women and men. Mean IgM levels were found to be highest in the XXX group, intermediate in normal women, and lowest in men; these differences were statistically significant. Mean IgM values obtained from seven XXY and three XXXY cases were almost identical with those of normal women and XXX women respectively. No such sex linkage was observed for IgA and IgG levels. These results support the suggestion that the serum level of IgM is related to the number of X chromosomes present.
摘要
对28名额外有一条X染色体（XXX）的女性以及数量相同的年龄匹配的正常女性和男性测定了血清免疫球蛋白（Ig）G、M和A水平。发现XXX组的平均IgM水平最高，正常女性居中，男性最低；这些差异具有统计学意义。从7例XXY和3例XXXY病例获得的平均IgM值分别与正常女性和XXX女性的几乎相同。未观察到IgA和IgG水平存在这种性连锁关系。这些结果支持了IgM血清水平与所存在的X染色体数量有关的观点。
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