Siegler A M, Kontopoulos V, Wang C F
Fertil Steril. 1980 Jul;34(1):46-9.
Twenty-six New Zealand White rabbits were randomly assigned to control or treated groups. In the treated group, the rabbits were medicated with either dexamethasone or ibuprofen. The injuries were made as standard as possible for each animal. The animals were killed 2 to 3 weeks postoperatively and the extent of adhesions was evaluated. Ibuprofen appeared to inhibit the formation of significant adhesions as compared with adhesion formation in untreated control animals, and the results seemed as effective as in the dexamethasone-treated animals. Further studies should be performed to substantiate these initial observations and to determine the most effective dosage. Ibuprofen may have a potential place in tubal surgery.
26只新西兰白兔被随机分为对照组和治疗组。在治疗组中，兔子分别用 dexamethasone（地塞米松）或布洛芬进行药物治疗。对每只动物尽可能按照标准造成损伤。术后2至3周处死动物，评估粘连程度。与未治疗的对照动物相比，布洛芬似乎能抑制明显粘连的形成，其结果与用地塞米松治疗的动物一样有效。应进行进一步研究以证实这些初步观察结果，并确定最有效的剂量。布洛芬在输卵管手术中可能有潜在的应用价值。
